After receiving a call from the DRI's Clinical Cell Transplant Team, Wendy Peacock became the first patient transplanted in our FDA-approved Phase I/II clinical trial to test the omentum as a new implant site for a DRI BioHub, a bioengineered “mini-organ” that mimics the native pancreas to restore natural insulin production in people with type 1 diabetes. Within days after the transplant procedure, Wendy was able to discontinue insulin therapy, as she began producing insulin on her own for the first time since being diagnosed with type 1 diabetes. Read the News Release>
In this first-ever clinical trial, researchers will evaluate whether the omentum is a better home for the islets than the liver, the traditional transplant site. The donor islet cells were implanted using a biologic, fully re-absorbable scaffold technique - referred to as a "biodegradable scaffold," one of the DRI BioHub platforms. This scaffold is a combination of the patient's own plasma, the liquid part of the blood that does not contain any cells, together with thrombin, a commonly-used, clinical-grade enzyme.
The DRI's preliminary findings have shown that islets in the omentum can survive and function long term. This clinical trial is an important first step in identifying an optimal location in the body for a DRI BioHub.
Learn more about the DRI BioHub and the DRI's strategy for reaching a biological cure - to restore natural insulin production and normalize blood sugar levels without imposing other risks.
DRI tv is hosted by Benno Schmidt, an award-winning and well-known television journalist and producer who was diagnosed with type 1 diabetes in 1990. Benno is also the host of dLife television and his work has appeared on Sunday Morning, The Early Show, NBC Nightly News, The Today Show, MSNBC, CNN and many other news outlets.
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Have questions? Read the Pilot Trial FAQ.
If you are interested in applying for this Phase I/II trial and future clinical trials, you can download the Islet Transplant Application form here.
Learn more about the development of the BioHub mini organ to restore natural insulin production in those living with diabetes.
Watch the BioHub video>>