The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1. Journal of Autoimmunity, 2007.
A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. Journal of Autoimmunity, 2007.
14th Annual International HLA and Immunogenetics Workshop: Report on the HLA component of type 1 diabetes. Tissue Antigens, 2007.
Induction of auto-reactive regulatory T cells by stimulation with immature autologous dendritic cells Immunol. Invest., 2007
The Miami Results on Porcine Islet-Sertoli Cell Xenotransplantation. Xenotransplantation, 2007.
Alternative Splicing of G6PC2, the Gene Coding for the Islet-Specific Glucose-6-phosphatase Catalytic Subunit-Related Protein (IGRP), Results in Differential Expression in Human Thymus and Spleen Compared With Pancreas. Diabetologia, 2006.
D6S265*15 Marks a DRB1*15, DQB1*0602 Haplotype Associated With Attenuated Protection
From Type 1 Diabetes Mellitus. Diabetologia, 2005.
A functional CD40 receptor is expressed in pancreatic beta cells. Diabetologia, 2005
Dendritic Cells in Human Thymus and Periphery Display a Proinsulin Epitope in a Transcription-Dependent, Capture-Independent Fashion. The Journal of Immunology, 2005.
Essential role for interleukin-2 for CD4+ and CD25+ T regulatory cell development
during the neonatal period. Journal of Experimental Medicine, 2005.
Systemic Overexpression of IL-10 Fails to Protect Allogeneic Islet Transplants in Nonobese Diabetic Mice.Transplantation, 2005
Prolonged Allogeneic Islet Graft Survival by Protoporphyrins. Cell Transplantation, 2005.
Central and peripheral autoantigen presentation in immune tolerance.
Immunology, 2004.
Clinical Islet Transplantation: Advances and Immunological Challenges. Nature Reviews/Immunology, 2004.
Targeted Bone Marrow Radioablation with Samarium-Lexidronam Promotes Allogeneic Hematopoietic Chimerism and Donor-Specific Immunologic Hyporesponsiveness. Transplantation, 2004
Tolerance, Not Immunity, Crucially Depends on IL-2.
Nature Reviews - Immunology, 2004.
Peptide-based treatment for autoimmune diseases: learning how to handle
a double-edged sword. Journal of Clinical Investigation, 2003.
Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice. Diabetes, 2003
Islet transplantation: immunological perspectives. Current Opinion in Immunology, 2003.
CD4+ Regulatory T Cells Prevent Lethal Autoimmunity In IL-2R CD4+ beta-deficient mice: Implications for the Nonredundant Function of CD4+ IL-2. Immunity, 2002.
Lymphoid organs contain diverse cells expressing self molecules.
Nature Immunology, 2002.
Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen. Diabetes, 2001.
Self-antigen-presenting cells expressing diabetes-associated autoantigens exist
in both thymus and peripheral lymphoid organs. Journal of Clinical Investigation, 2001.
Sequence Analysis of the Diabetes-Protective Human Leukocyte Antigen-DQB1*0602 Allele
in Unaffected, Islet Cell Antibody-Positive First Degree Relatives and in Rare Patients
with Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 1999.
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proceedings of the National Academy of Science, 1999.
Long-Term Survival and Function of Intrahepatic Islet Allografts in Baboons Treated with Humanized Anti-CD154. Diabetes, 1999
The insulin gene is transcribed in the human thymus and transcription levels
correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
Nature Genetics, 1997.
HLA-DQB1*0602 is Associated with Dominant Protection from Diabetes Even Among Islet Cell Antibody-Positive First-Degree Relatives of Patients with IDDM. Diabetes, 1995.