Selected Research PublicationsIslet Biology, Potency and Engraftment

Glutamate is a Positive Autocrine Signal for Glucagon Release. Cell Metabolism, 2008

Noninvasive in vivo imaging of pancreatic islet cell biology.
Nature Medicine, 2008

Rapamycin Impairs In Vivo Proliferation of Islet Beta Cells.
Transplantation, 2007

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation.
Diabetologia, 2007

Interference with Tissue Factor Prolongs Intrahepatic Islet Allografts Survival in a Nonhuman Primate Marginal Mass Model.
  Transplantation, 2007

The L-isoform but not D-isoforms of a JNK inhibitory peptide protects pancreatic B-cells.
  Biochemical and Biophysical Research Communications, 2007

Therapeutic Approaches to Counteract Immediate Blood-Mediated Inflammatory Reaction in Islet Transplantation.  Transplantation, 2006

CD40-CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets

Diabetes, 2006

Isoform-specific insulin receptor signaling involves different plasma membrane domains
.
The Journal of Cell Biology, 2006

The Unique Cytoarchitecture of Human Pancreatic Islets Has Implications for Islet Cell Function
, Proceedings of the National Academy of Science, 2006

Transthyretin Constitutes a Functional Component In Pancreatic Beta Cell
Stimulus-Secretion Coupling,
Proceedings of the National Academy of Science, 2005

A Novel Method for the Assessment of Cellular Composition and Beta-Cell
Viability in Human Islet Preparation.
American Journal of Transplantation, 2005.

Donor Islet Endothelial Cells Participate in Formation of Functional Vessels within
Pancreatic Islet Grafts.
Diabetes, 2005. 

Adenoviral Gene Transfer of EPO Confers Cytoprotection to Isolated Pancreatic Islets. Transplantation, 2004.

Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets. BBRC, 2004.

Protecting pancreatic b cells.IUBMB Life, 2004

Removal of Ca2+ Channel Beta3 Enhances Ca2+ Oscillation Frequency and Insulin Exocytosis.
Cell 2004.

HO-1 fused to a TAT Peptide Transduces and Protects Pancreatic b-cells.
BBRC, 2003

Human, Nonhuman Primate, and Rat Pancreatic Islets Express EPO Receptors.Transplantation, 2003

Adeno-Associated Virus Transduction of Islets with Interleukin-4 Results in Impaired Metabolic Function in Syngeneic Marginal Islet Mass Transplantation. Transplantation, 2002.

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic b-cells.  Molecular Cell, 2001

Early Assessment of Apoptosis in Isolated Islets of Langerhans.
Transplantation, 2001.

Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. Transplantation, 2001

Factors influencing Islet of Langerhans graft function and monitoring.
CCA, 2001.

HO-1 Induction in Islet Cells Results in Protection and Improved Function.
Diabetes, 2001.

Proteins Linked to a Protein Transduction Domain Efficiently Transduce Pancreatic Islets.
Diabetes, 2001.

Short-term regulation of insulin gene transcription by glucose. Proc. Natl. Acad. Sci, 1998

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/P1-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways.  Molecular Cell, 1998

Transplantation of Allogenic Islets of Langerhans in the Rat Liver. Diabetes, 1998.

Successful Long-Term Survival of Pancreatic Islet Allografts in Spontaneous or Pancreatectomy-induced Diabetes in Dogs. Journal of American Diabetes Association, 1985.

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