Drug Discovery Initiative

Blocking rejection

 

What the animation shows

The small green, yellow and blue strands at the center of this 3-dimensional structure comprise the CD-154 co-stimulatory molecule which plays a central role in the rejection process.

The three longer strands are the antibody used to successfully block the signal in previous studies. However, these antibodies caused side effects that could be eliminated if adequate small molecules can be identified.

This is a major focus of the DRI’s Drug Discovery team.