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Venous Sac 

A Natural Container

Could the BioHub be placed inside of a vein? So far, this approach is proving promising.

In a recent study published in the journal Transplantation, the DRI and DRI Federation collaborators in Edmonton, Canada, and Tbilisi, Georgia, transplanted rodent islet cells in an isolated portion of a rodent vein. The cells successfully functioned and restored normal blood glucose levels. By “tying off” the ends of a section of the vein, 
researchers created a “venous sac” and filled it
 with islets. An adjacent artery provided blood
flow.

The venous sac contains other cell types known to promote islet health and normal function. To build on these important findings, the DRI and its partners in Edmonton and Tbilisi are conducting trials of the venous sac in pre‐clinical models.

Venous Sac
By tying off a section of a vein, researchers create a "venous sac" to serve as a natural container for a BioHub. An adjacent artery would provide critical oxygen and nutrients.

The DRI BioHub mini organ mimics the native pancreas
Learn more about the development of the BioHub mini organ to restore natural insulin production in those living with diabetes.
Watch the BioHub video>>

DRI and collaborators have tested the venous sac in pre-clinical models
The DRI and collaborators in Tbilisi, Georgia, are testing the use of a venous sac in pre-clinical models.  

  • Read more: Published study in Transplantation 

 

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