The DRI BioHub is a bioengineered "mini organ" that mimics the native pancreas. It contains real insulin-producing cells that can sense blood sugar and release the precise amount of insulin needed - in real time.

Re-Educating the Immune System

Re-Educating the Immune System

Restoring immune system balance to protect insulin-producing cells and prevent the recurrence of the autoimmune process, which mistakenly destroys a person's own cells.

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Increasing Cell Supply

Increasing Cell Supply

Indentifying, developing and/or regenerating a limitless supply of cells to sense glucose levels and produce insulin.

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Encapsulation

Encapsulation

Protective barriers that conform to the individual size and shape of each islet and allow the free flow of nutrients, glucose and insulin while screening out harmful immune system cells.

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Structural Housing

Structural Housing

Three dimensional structure provides spacing and a physical site, similar to the native pancreas, that can be monitored and modified, and retrieved, if necessary.

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Oxygen Delivery

Oxygen Delivery

Oxygen-generating materials provide the critical oxygen needed until new blood vessels grow.

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Localized Drug Delivery

Localized Drug Delivery

Local delivery of low-dose drugs directly into the site can reduce inflammation and protect islets from an immune attack, with the goal of eliminating systemic anti-rejection drugs.

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Co-delivery of "Helper" Cells

Co-delivery of "Helper" Cells

Certain cells in the body that have beneficial properties can be added to help promote long-term islet survival.

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Clinical Trials

Advancing promising research and moving cutting-edge therapies to patients.

 

A cure is within reach at the Diabetes Research Institute

A Cure Within Reach

A cure would mean restoring natural insulin production and normalizing blood sugar levels without imposing other risks.

DRI clinical trials are already dramatically improving the lives of people with type 1 diabetes who are now living insulin free.

As we continue to develop the DRI BioHub, a ‘mini-organ’ delivering insulin in real time, we are working to eliminate the need for anti rejection drugs, block autoimmunity, and create more insulin-producing cells. But continuing this research is only possible with your support.

Support Our Research

 

Supporters, Researchers and Patients

Our Team in the Fight For a Cure

Supporter Spotlight

Why I Support the DRI

Supermodel Izabel Goulart supports the DRI to help her brother. "The Diabetes Research Institute fights every day to find a cure," she says.

How You Can Help

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Researcher Spotlight

Jay Skyler, M.D., Deputy Director

Dr. Skyler explains the different components of the immune system and how addressing each is key to tackling the challenges of type 1 diabetes.

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Meet Other Researchers

Patient Spotlight

"I'm alive and well and better than ever."

DRI islet transplant recipient Karla Edge has been living free from insulin therapy for more than 11 years -- and living a life she's always dreamed of.

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