The DRI BioHub is a bioengineered "mini organ" that mimics the native pancreas. It contains real insulin-producing cells that can sense blood sugar and release the precise amount of insulin needed - in real time.

Re-Educating the Immune System

Re-Educating the Immune System

Restoring immune system balance to protect insulin-producing cells and prevent the recurrence of the autoimmune process, which mistakenly destroys a person's own cells.

Learn More

Increasing Cell Supply

Increasing Cell Supply

Indentifying, developing and/or regenerating a limitless supply of cells to sense glucose levels and produce insulin.

Learn More

Encapsulation

Encapsulation

Protective barriers that conform to the individual size and shape of each islet and allow the free flow of nutrients, glucose and insulin while screening out harmful immune system cells.

Learn More

Structural Housing

Structural Housing

Three dimensional structure provides spacing and a physical site, similar to the native pancreas, that can be monitored and modified, and retrieved, if necessary.

Learn More

Oxygen Delivery

Oxygen Delivery

Oxygen-generating materials provide the critical oxygen needed until new blood vessels grow.

Learn More

Localized Drug Delivery

Localized Drug Delivery

Local delivery of low-dose drugs directly into the site can reduce inflammation and protect islets from an immune attack, with the goal of eliminating systemic anti-rejection drugs.

Learn More

Co-delivery of "Helper" Cells

Co-delivery of "Helper" Cells

Certain cells in the body that have beneficial properties can be added to help promote long-term islet survival.

Learn More

Clinical Trials

Advancing promising research and moving cutting-edge therapies to patients.

 

A cure is within reach at the Diabetes Research Institute

A Cure Within Reach

A cure would mean restoring natural insulin production and normalizing blood sugar levels without imposing other risks.

DRI clinical trials are already dramatically improving the lives of people with type 1 diabetes who are now living insulin free.

As we continue to develop the DRI BioHub, a ‘mini-organ’ delivering insulin in real time, we are working to eliminate the need for anti rejection drugs, block autoimmunity, and create more insulin-producing cells. But continuing this research is only possible with your support.

Support Our Research

 

Supporters, Researchers and Patients

Our Team in the Fight For a Cure

Supporter Spotlight

Why I Support the DRI

Jennifer Ross has never let diabetes hold her back - but a day doesn't go by that she doesn't dream of finding a cure.

How You Can Help

More Supporter Stories

Researcher Spotlight

David Baidal, M.D., Cell Transplant Program

Dr. Baidal speaks about the impact the DRI has made in the field of diabetes research and the vision for moving ahead to find a cure.

Learn More

Meet Other Researchers

Patient Spotlight

"I'm no longer driving a 'lethal weapon.'"

For DRI islet transplant recipient Jill Eastman, it's been 12 years of living free from worry and the risk of hurting herself and others.

Learn More About clinical Trials

View Other Patient Stories