Miller School of Medicine

Immunobiology of Diabetes and Transplantation

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Association of Serum MicroRNAs with Islet Autoimmunity, disease progression adn metabolic impairment in relatives at risk of type 1 type diabetes. Diabetologia, 2017 

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy. Curr Diab Rep, 2016.

G-CSF and Exenatide might be associated with increased long-term survival of allogeneic pancreatic islet grafts. PLOS one, 2016

Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model. Cell Metabolism, 2016

Selective IL-2 responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Support the Use of Low Dose IL-2 Therapy in Type 1 Diabetes. Diabetes, 2015.

Low-dose interleukin-2 fosters a dose-dependent regulatory T celltuned milieu in T1D patients. Journal of Autoimmunity, 2015.

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease, Immunotherapy, 2014 

New Insight on Human Type 1 Diabetes Biology:nPOD and nPOD-Transplantation. Transplantation, 2014.

Human T regulatory cells are intrinsically more sensitive to IL-2-induced signal transduction than T effector and T memory cells.  Keystone Symposia, 2013.

Effect of the Purinergic Inhibitor Oxidized - ATP in a Model of Islet Allograft RejectionDiabetes, 2013.

Long Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7Circulation, 2013.

Induction Therapy with Autologous Mesenchymal Living-Related Kidney TransplantsJAMA, 2012.

The Anterior Chamber of the Eye Allows Longitudinal, Intravital Imaging of CTL's to Study Islet ImmunobiologyJCI, 2012.

Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic IsletsJournal of Transplantation, 2012.

Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone. Pharmazie, 2012.

High Resolution, Non-invasive Longitudinal Live Imaging of Immune ResponsesPNAS, 2011.

Recurrence of Autoimmunity Following Pancreas Transplantation. Curr Diab Rep, 2011.

Prevention of Autoimmune Diabetes and Induction of Beta-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy. Diabetes, 2012.

Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man. Diabetes, 2011.

Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation. Pharmazie, 2010.

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates. Diabetes, 2010.

Recurrence of Type 1 Diabetes After Pancreas-Kidney Transplantation Despite Immunosuppression Associated with Autoantibodies and Pathogenic Autoreactive CD4 T Cells. Diabetes, 2010.

The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1.
 Journal of Autoimmunity, 2007.

A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. Journal of Autoimmunity, 2007.

14th Annual International HLA and Immunogenetics Workshop: Report on the HLA component of type 1 diabetes. Tissue Antigens, 2007.

Induction of auto-reactive regulatory T cells by stimulation with immature autologous dendritic cells. Immunol. Invest, 2007.

The Miami Results on Porcine Islet-Sertoli Cell Xenotransplantation. Xenotransplantation, 2007.

Alternative Splicing of G6PC2, the Gene Coding for the Islet-Specific Glucose-6-phosphatase Catalytic Subunit-Related Protein (IGRP), Results in Differential Expression in Human Thymus and Spleen Compared With Pancreas. Diabetologia, 2006.

D6S265*15 Marks a DRB1*15, DQB1*0602 Haplotype Associated With Attenuated Protection From Type 1 Diabetes Mellitus. Diabetologia, 2005.

A functional CD40 receptor is expressed in pancreatic beta cells. Diabetologia, 2005.

Dendritic Cells in Human Thymus and Periphery Display a Proinsulin Epitope in a Transcription-Dependent, Capture-Independent Fashion. The Journal of Immunology, 2005.

Essential role for interleukin-2 for CD4+ and CD25+ T regulatory cell development during the neonatal period. Journal of Experimental Medicine, 2005.

Systemic Overexpression of IL-10 Fails to Protect Allogeneic Islet Transplants in Nonobese Diabetic Mice. Transplantation, 2005.

Prolonged Allogeneic Islet Graft Survival by Protoporphyrins. Cell Transplantation, 2005.

Central and peripheral autoantigen presentation in immune tolerance. Immunology, 2004.

Clinical Islet Transplantation: Advances and Immunological Challenges. Nature Reviews/Immunology, 2004.

Targeted Bone Marrow Radioablation with Samarium-Lexidronam Promotes Allogeneic Hematopoietic Chimerism and Donor-Specific Immunologic Hyporesponsiveness. Transplantation, 2004.

Tolerance, Not Immunity, Crucially Depends on IL-2. Nature Reviews - Immunology, 2004.

Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword. Journal of Clinical Investigation, 2003.

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice. Diabetes, 2003.

Islet transplantation: immunological perspectives. Current Opinion in Immunology, 2003.

CD4+ Regulatory T Cells Prevent Lethal Autoimmunity In IL-2R CD4+ beta-deficient mice: Implications for the Nonredundant Function of CD4+ IL-2. Immunity, 2002.

Lymphoid organs contain diverse cells expressing self molecules. Nature Immunology, 2002.

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen. Diabetes, 2001.

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. Journal of Clinical Investigation, 2001.

Sequence Analysis of the Diabetes-Protective Human Leukocyte Antigen-DQB1*0602 Allele in Unaffected, Islet Cell Antibody-Positive First Degree Relatives and in Rare Patients with Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 1999.

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proceedings of the National Academy of Science, 1999.

Long-Term Survival and Function of Intrahepatic Islet Allografts in Baboons Treated with Humanized Anti-CD154. Diabetes, 1999.

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nature Genetics, 1997.

HLA-DQB1*0602 is Associated with Dominant Protection from Diabetes Even Among Islet Cell Antibody-Positive First-Degree Relatives of Patients with IDDM. Diabetes, 1995.

 

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