Miller School of Medicine

Islet Biology, Potency and Engraftment

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Proteomic profiling of human islets collected from frozen pancreata usinglaser capture microdissection.  Journal of Proteomics, 2016.

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. Journal of Experimental Medicine, 2014.

Transplantation into the Anterior Chamber of the Eye for Longitudinal, Noninvasive In vivo Imaging with Single-cell Resolution in Real-time. Jove, 2013.

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research. Jove, 2012.

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet functionPNAS, 2012.

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas. Cell Metabolism, 2011.

The Thyroid Hormone-Inactivating Type III Deiodinase is Expressed in Mouse and Human Beta Cells and its Targeted Inactivation Impairs Insulin Secretion. Endocrinology, 2011.

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humansNature Medicine, 2011.

Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice. FASEB, 2011.

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization Diabetes, 2011.

The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes. Diabetologia, 2011.

Bone Marrow as an Alternative Site for Islet Transplantation.  Blood, 2009.

Quantitative Differential Expression Analysis Reveals miR-7 as Major Islet microRNA. Biochem. Biophys. Res. Commun., 2008.

Glutamate is a Positive Autocrine Signal for Glucagon Release.
 Cell Metabolism, 2008.

Noninvasive in vivo imaging of pancreatic islet cell biology. Nature Medicine, 2008.

Rapamycin Impairs In Vivo Proliferation of Islet Beta Cells. Transplantation, 2007.

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia, 2007.

Interference with Tissue Factor Prolongs Intrahepatic Islet Allografts Survival in a Nonhuman Primate Marginal Mass Model. Transplantation, 2007.

The L-isoform but not D-isoforms of a JNK inhibitory peptide protects pancreatic B-cells. Biochemical and Biophysical Research Communications, 2007.

Therapeutic Approaches to Counteract Immediate Blood-Mediated Inflammatory Reaction in Islet Transplantation. Transplantation, 2006.

CD40-CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets. Diabetes, 2006.

Isoform-specific insulin receptor signaling involves different plasma membrane domains. The Journal of Cell Biology, 2006.

The Unique Cytoarchitecture of Human Pancreatic Islets Has Implications for Islet Cell Function. Proceedings of the National Academy of Science, 2006.

Transthyretin Constitutes a Functional Component In Pancreatic Beta Cell Stimulus-Secretion Coupling. Proceedings of the National Academy of Science, 2005.

A Novel Method for the Assessment of Cellular Composition and Beta-Cell Viability in Human Islet Preparation. American Journal of Transplantation, 2005.

Donor Islet Endothelial Cells Participate in Formation of Functional Vessels within Pancreatic Islet Grafts. Diabetes, 2005.

Adenoviral Gene Transfer of EPO Confers Cytoprotection to Isolated Pancreatic Islets. Transplantation, 2004.

Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets. BBRC, 2004.

Protecting pancreatic b cells. IUBMB Life 2004.

Removal of Ca2+ Channel Beta3 Enhances Ca2+ Oscillation Frequency and Insulin Exocytosis. Cell 2004.

HO-1 fused to a TAT Peptide Transduces and Protects Pancreatic b-cells. BBRC, 2003.

Human, Nonhuman Primate, and Rat Pancreatic Islets Express EPO Receptors. Transplantation, 2003.

Adeno-Associated Virus Transduction of Islets with Interleukin-4 Results in Impaired Metabolic Function in Syngeneic Marginal Islet Mass Transplantation. Transplantation, 2002.

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic b-cells. Molecular Cell, 2001.

Early Assessment of Apoptosis in Isolated Islets of Langerhans. Transplantation, 2001.

Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. Transplantation, 2001.

Factors influencing Islet of Langerhans graft function and monitoring. CCA, 2001.

HO-1 Induction in Islet Cells Results in Protection and Improved Function. Diabetes, 2001.

Proteins Linked to a Protein Transduction Domain Efficiently Transduce Pancreatic Islets. Diabetes, 2001.

Short-term regulation of insulin gene transcription by glucose. Proc. Natl. Acad. Sci, 1998.

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/P1-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways. Molecular Cell, 1998.

Transplantation of Allogenic Islets of Langerhans in the Rat Liver. Diabetes, 1998.

Successful Long-Term Survival of Pancreatic Islet Allografts in Spontaneous or Pancreatectomy-induced Diabetes in Dogs. Journal of American Diabetes Association, 1985.


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