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Immune Tolerance and Autoimmunity

Immunomodulation Followed By Antigen-Specific T-reg Infusion Controls Islet Autoimunity
Diabetes, 2019

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice
Diabetologia, 2019

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate
Diabetologia, 2019

The Folate Cycle As a Cause of Natural Killer Cell Dysfunction and Viral Etiology in Type 1 Diabetes
Frontiers in Endocrinology, 2017

Administration of Vitamin D and High Dose of Omega 3 to Sustain Remission of Type 1 Diabetes
European Review for Medical and Pharmacological Sciences, 2018

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction
Journal of Medicinal Chemistry, 2017

Autoreactive T cells in type 1 diabetes
The Journal of Clinical Investigation, 2017

Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes
Diabetologia, 2017 

A Comprehensive Metabolomics Study to Assess Longitudinal Biochemical Changes and Potential Early Biomarkers in NOD Mice that Progress to Diabetes
Journal of Proteome Research, 2017

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration type 1 diabetes
Scientific Reports, 2017

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy
Current Diabetes Reports, 2016

G-CSF and Exenatide might be associated with increased long-term survival of allogeneic pancreatic islet grafts
PLOS one, 2016

Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
Cell Metabolism, 2016

Selective IL-2 responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Support the Use of Low Dose IL-2 Therapy in Type 1 Diabetes
Diabetes, 2015.

Low-dose Interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
Journal of Autoimmunity, 2015

Low-dose Interleukin-2 in the treatment of autoimmune disease
Immunotherapy, 2014

New Insight on Human Type 1 Diabetes Biology: nPOD and nPOD-Transplantation
Transplantation, 2014

Human T regulatory cells are intrinsically more sensitive to IL-2-induced signal transduction than T effector and T memory cells 
Keystone Symposia, 2013.

Effect of the Purinergic Inhibitor Oxidized - ATP in a Model of Islet Allograft Rejection 
Diabetes, 2013.

Long Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7 
Circulation, 2013.

Induction Therapy with Autologous Mesenchymal Living-Related Kidney Transplants 
JAMA, 2012.

The Anterior Chamber of the Eye Allows Longitudinal, Intravital Imaging of CTL's to Study Islet Immunobiology 
JCI, 2012.

Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets 
Journal of Transplantation, 2012.

Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone
Pharmazie, 2012.

High Resolution, Non-invasive Longitudinal Live Imaging of Immune Responses 
PNAS, 2011.

Recurrence of Autoimmunity Following Pancreas Transplantation
Curr Diab Rep, 2011.

Prevention of Autoimmune Diabetes and Induction of Beta-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
Diabetes, 2012.

Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
Diabetes, 2011.

Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation
Pharmazie, 2010.

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates
Diabetes, 2010.

Recurrence of Type 1 Diabetes After Pancreas-Kidney Transplantation Despite Immunosuppression Associated with Autoantibodies and Pathogenic Autoreactive CD4 T Cells
Diabetes, 2010.

Insulin Protein and Proliferation in Ductal Cells in the Transplanted Pancreas of Patients with Type 1 Diabetes and Recurrence of Autoimmunity 
Diabetologia, 2008.

The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1 
Journal of Autoimmunity, 2007.

A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease 
Journal of Autoimmunity, 2007.

14th Annual International HLA and Immunogenetics Workshop: Report on the HLA component of type 1 diabetes 
Tissue Antigens, 2007.

Induction of auto-reactive regulatory T cells by stimulation with immature autologous dendritic cells 
Immunol. Invest, 2007.

The Miami Results on Porcine Islet-Sertoli Cell Xenotransplantation 
Xenotransplantation, 2007.

Alternative Splicing of G6PC2, the Gene Coding for the Islet-Specific Glucose-6-phosphatase Catalytic Subunit-Related Protein (IGRP), Results in Differential Expression in Human Thymus and Spleen Compared With Pancreas 
Diabetologia, 2006.

D6S265*15 Marks a DRB1*15, DQB1*0602 Haplotype Associated With Attenuated Protection From Type 1 Diabetes Mellitus 
Diabetologia, 2005.

A functional CD40 receptor is expressed in pancreatic beta cells 
Diabetologia, 2005.

Dendritic Cells in Human Thymus and Periphery Display a Proinsulin Epitope in a Transcription-Dependent, Capture-Independent Fashion 
The Journal of Immunology, 2005.

Essential role for interleukin-2 for CD4+ and CD25+ T regulatory cell development during the neonatal period
Journal of Experimental Medicine, 2005.

Systemic Overexpression of IL-10 Fails to Protect Allogeneic Islet Transplants in Nonobese Diabetic Mice 
Transplantation, 2005.

Prolonged Allogeneic Islet Graft Survival by Protoporphyrins
Cell Transplantation, 2005.

Central and peripheral autoantigen presentation in immune tolerance 
Immunology, 2004.

Clinical Islet Transplantation: Advances and Immunological Challenges 
Nature Reviews/Immunology, 2004.

Targeted Bone Marrow Radioablation with Samarium-Lexidronam Promotes Allogeneic Hematopoietic Chimerism and Donor-Specific Immunologic Hyporesponsiveness 
Transplantation, 2004.

Tolerance, Not Immunity, Crucially Depends on IL-2 
Nature Reviews - Immunology, 2004.

Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword 
Journal of Clinical Investigation, 2003.

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice 
Diabetes, 2003.

Islet transplantation: immunological perspectives 
Current Opinion in Immunology, 2003.

CD4+ Regulatory T Cells Prevent Lethal Autoimmunity In IL-2R CD4+ beta-deficient mice: Implications for the Nonredundant Function of CD4+ IL-2
Immunity, 2002.

Lymphoid organs contain diverse cells expressing self molecules 
Nature Immunology, 2002.

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen 
Diabetes, 2001.

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
Journal of Clinical Investigation, 2001.

Sequence Analysis of the Diabetes-Protective Human Leukocyte Antigen-DQB1*0602 Allele in Unaffected, Islet Cell Antibody-Positive First Degree Relatives and in Rare Patients with Type 1 Diabetes 
The Journal of Clinical Endocrinology & Metabolism, 1999.

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
Proceedings of the National Academy of Science, 1999.

Long-Term Survival and Function of Intrahepatic Islet Allografts in Baboons Treated with Humanized Anti-CD154
Diabetes, 1999.

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes 
Nature Genetics, 1997.

HLA-DQB1*0602 is Associated with Dominant Protection from Diabetes Even Among Islet Cell Antibody-Positive First-Degree Relatives of Patients with IDDM
Diabetes, 1995.

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