DRI and Foundation News

Islet Biology and Cell Processing

Proteomic profiling of human islets collected from frozen pancreata usinglaser capture microdissection 
Journal of Proteomics, 2016.

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance
Journal of Experimental Medicine, 2014.

Transplantation into the Anterior Chamber of the Eye for Longitudinal, Noninvasive In vivo Imaging with Single-cell Resolution in Real-time
Jove, 2013.

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
Jove, 2012.

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function
PNAS, 2012.

Beneficial Effects of Ischemic Preconditioning on Pancreas Cold Preservation
Cell Transplantation, 2012.

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas
Cell Metabolism, 2011.

The Thyroid Hormone-Inactivating Type III Deiodinase is Expressed in Mouse and Human Beta Cells and its Targeted Inactivation Impairs Insulin Secretion
Endocrinology, 2011.

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans 
Nature Medicine, 2011.

Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice
FASEB, 2011.

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization 
Diabetes, 2011.

The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes
Diabetologia, 2011.

Bone Marrow as an Alternative Site for Islet Transplantation 
Blood, 2009.

Quantitative Differential Expression Analysis Reveals miR-7 as Major Islet microRNA
Biochem. Biophys. Res. Commun., 2008.

Glutamate is a Positive Autocrine Signal for Glucagon Release
Cell Metabolism, 2008.

Noninvasive in vivo imaging of pancreatic islet cell biology 
Nature Medicine, 2008.

Rapamycin Impairs In Vivo Proliferation of Islet Beta Cells 
Transplantation, 2007.

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation
Diabetologia, 2007.

Interference with Tissue Factor Prolongs Intrahepatic Islet Allografts Survival in a Nonhuman Primate Marginal Mass Model
Transplantation, 2007.

The L-isoform but not D-isoforms of a JNK inhibitory peptide protects pancreatic B-cells
Biochemical and Biophysical Research Communications, 2007.

Therapeutic Approaches to Counteract Immediate Blood-Mediated Inflammatory Reaction in Islet Transplantation
Transplantation, 2006.

Improved Human Islet Isolation Using Nicotinamide
American Journal of Transplantation, 2006.

CD40-CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets
Diabetes, 2006.

Isoform-specific insulin receptor signaling involves different plasma membrane domains
The Journal of Cell Biology, 2006.

The Unique Cytoarchitecture of Human Pancreatic Islets Has Implications for Islet Cell Function
Proceedings of the National Academy of Science, 2006.

Transthyretin Constitutes a Functional Component In Pancreatic Beta Cell Stimulus-Secretion Coupling
Proceedings of the National Academy of Science, 2005.

Rescue Purification Maximizes the Use of Human Islet Preparations for Transplantation
American Journal of Transplantation, 2005.

A Novel Method for the Assessment of Cellular Composition and Beta-Cell Viability in Human Islet Preparation
American Journal of Transplantation, 2005.

Donor Islet Endothelial Cells Participate in Formation of Functional Vessels within Pancreatic Islet Grafts
Diabetes, 2005.

Adenoviral Gene Transfer of EPO Confers Cytoprotection to Isolated Pancreatic Islets
Transplantation, 2004.

Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets
BBRC, 2004.

Protecting pancreatic b cells
IUBMB Life 2004.

Removal of Ca2+ Channel Beta3 Enhances Ca2+ Oscillation Frequency and Insulin Exocytosis
Cell 2004.

HO-1 fused to a TAT Peptide Transduces and Protects Pancreatic b-cells
BBRC, 2003.

Human, Nonhuman Primate, and Rat Pancreatic Islets Express EPO Receptors
Transplantation, 2003.

Adeno-Associated Virus Transduction of Islets with Interleukin-4 Results in Impaired Metabolic Function in Syngeneic Marginal Islet Mass Transplantation
Transplantation, 2002.

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic b-cells
Molecular Cell, 2001.

Early Assessment of Apoptosis in Isolated Islets of Langerhans
Transplantation, 2001.

Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis 
Transplantation, 2001.

Factors influencing Islet of Langerhans graft function and monitoring 
CCA, 2001.

HO-1 Induction in Islet Cells Results in Protection and Improved Function 
Diabetes, 2001.

Proteins Linked to a Protein Transduction Domain Efficiently Transduce Pancreatic Islets
Diabetes, 2001.

Short-term regulation of insulin gene transcription by glucose 
Proc. Natl. Acad. Sci, 1998.

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/P1-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways 
Molecular Cell, 1998.

Transplantation of Allogenic Islets of Langerhans in the Rat Liver
Diabetes, 1998.

A Simple Method of Staining Fresh and Cultured Islets
Transplantation, 1988.

Automated method for isolation of human pancreatic islets
Diabetes, 1988.

Successful Long-Term Survival of Pancreatic Islet Allografts in Spontaneous or Pancreatectomy-induced Diabetes in Dogs
Journal of American Diabetes Association, 1985.

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