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DRI's "Living Window" - a Novel Technique to Accelerate Research   

by Diabetes Research Institute on Thursday, April 21, 2011 at 10:12am on T1 Diabetes Cure - Global Headquarters and Diabetes Research Institute Facebook pages.

Hi everyone. We wanted to share some news about a new DRI advance. The DRI’s Cell Biology and Islet Physiology team developed a unique approach to observe transplanted cells and follow those same cells over time—in REAL time. We call it the “Living Window” and results of a pre-clinical pilot study are on Diabetologia online here.

The print edition will be out in May and the work will be featured on the cover.  Basically, our researchers have been transplanting islets into the anterior chamber of the eye (in mice) to watch the progression and development of nerves and vessels into the islets as well as monitor various immune responses as they occur. This technology is providing critical new data and will help design ways to improve islet replacement strategies and develop new, safer and specifically-targeted drugs to enhance cell function.

Based on the results in the rodent model, the team, led by Dr. Per-Olof Berggren, worked with colleagues from the world renown Bascom Palmer Eye Institute at the University of Miami to translate these findings to a model more relevant to clinical application (patients). The publication describes the promising results in a non-human primate.

The team was also notified that two additional papers were accepted for publication in major journals. We’ll report on these advances in future posts. In the meantime, you can learn a bit more about the “living window” by clicking here.


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